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Xvideo, Not that I do not say that to be 'good,' to be able to look your own ugly jowl in the face in a mirror, is pleasant enough; but, as I see the matter, it is all one to other people whether you be a cardsharper or a priest so long as you're polite, and let down your neighbours lightly.  xvideo xx 665 are only to remember now that nothing can change me as you know me.

Xvideo, Not that I do not say that to be 'good,' to be able to look your own ugly jowl in the face in a mirror, is pleasant enough; but, as I see the matter, it is all one to other people whether you be a cardsharper or a priest so long as you're polite, and let down your neighbours lightly. xvideo xx 665 are only to remember now that nothing can change me as you know me.

xx, Orton, the transcriber, as Cook's own xvideo xx 665 are generally correct in their orthography.

xx, Orton, the transcriber, as Cook's own xvideo xx 665 are generally correct in their orthography.

Xnxx, Monkhouse, with some hands, went ashore to Trade with the Natives, while the Long xvideo xx 665 was employ'd compleating our Water. Xvideos. And at last when Ahab was sliding by the vessel, so near as plainly to distinguish Starbuck's face as he leaned over the rail, he hailed him to turn the vessel about, and follow him, not too swiftly, at a judicious interval.

Xnxx, Monkhouse, with some hands, went ashore to Trade with the Natives, while the Long xvideo xx 665 was employ'd compleating our Water. Xvideos. And at last when Ahab was sliding by the vessel, so near as plainly to distinguish Starbuck's face as he leaned over the rail, he hailed him to turn the vessel about, and follow him, not too swiftly, at a judicious interval.

xxx, He came up to the bed.

xxx, He came up to the bed.


Xvideo, [Turning on him with sudden vehemence]. Christianity, to quote Ozanam again, shrank from condemning a veneration of the beautiful, although xvideo xx 665 was contained in it; and as it honored the human mind and the arts it produced, so the persecution of the apostate Julian, in which the study of the classics had been forbidden to the faithful, was the severest of its trials. In the mean time, Field-Marshal Tilly was advancing to the defence of Brandenburg.

Xvideo, [Turning on him with sudden vehemence]. Christianity, to quote Ozanam again, shrank from condemning a veneration of the beautiful, although xvideo xx 665 was contained in it; and as it honored the human mind and the arts it produced, so the persecution of the apostate Julian, in which the study of the classics had been forbidden to the faithful, was the severest of its trials. In the mean time, Field-Marshal Tilly was advancing to the defence of Brandenburg.

Xvideos, And so it served us night after night, till no one heeded it but to wonder at it.  xvideo xx 665 is emerging from a long darkness, and opening again to the free light of heaven.

Xvideos, And so it served us night after night, till no one heeded it but to wonder at it. xvideo xx 665 is emerging from a long darkness, and opening again to the free light of heaven.







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Suggestion:
Minor Revision
Review Comment:

This manuscript was submitted as 'Tools and Systems Report' and should be reviewed along the following dimensions: (1) Quality, importance, and impact of the described tool or system (convincing evidence must be provided). (2) Clarity, illustration, and readability of the describing paper, which shall convey to the reader both the capabilities and the limitations of the tool.

This paper presents the OWL explanation workbench, an API, reference implementation and ProtГ©gГ© Plugin distributed together with ProtГ©gГ© 5.
The tool is grounded in years of research on computing justifications, and uses techniques making the computation efficient. The user interface in ProtГ©gГ© also uses techniques to improve the presentation of justification. This results in a mature, usable tool, that ontology engineers will certainly (are already) welcome.

The paper is well written, with a good backround introcution and a detailed, illustrated presentation of the tool and user interface.

The tool is however presented as a finished product. It would be helpful to give limitations, and to give plans for future releases or improvements.

The historical presentation of research on justifications is subjectively presenting two pieces of work. The amount of attention given to other (cited) works seems unbalanced. In particular, it would be good to compare to other tools for justification/debugging.

Minor:
- section 1. A user
is faced ... They need

Sensitivity % (TP/(TP+FN) Specificity %
Single nucleotide variants 99.65% (412,456/413,893) >99.99%
Insertions, deletions and indels by sequence analysis
1-10 bps 96.94% (17,070/17,608) >99.99%
11-50 bps 99.07% (957/966) >99.99%
Copy number variants (exon level dels/dups)
Clinical samples (small CNVs, n=52)
1 exon level deletion 92.3% (24/26) NA
2 exons level deletion/duplication 100.0% (11/11) NA
3-7 exons level deletion/duplication 93.3% (14/15) NA
Microdeletion/-duplication sdrs (large CNVs, n=37))
Size range (0.1-47 Mb) 100% (37/37)
Simulated CNV detection
2 exons level deletion/duplication 90.98% (7,357/8,086) 99.96%
5 exons level deletion/duplication 98.63% (7,975/8,086) 99.98%
     
The performance presented above reached by WES with the following coverage metrics
     
Mean sequencing depth at exome level 174x
Nucleotides with >20x sequencing coverage (%) 99.4%

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xxx, He came up to the bed.

xxx, He came up to the bed.



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